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A separate meta-analysis that pooled results of trials in older adults with mild cognitive impairment found B-vitamin supplementation (6 to 24 months, depending on the trial) had no benefits on various cognitive parameters, including executive function, information processing speed, and episodic memory (90)

Dose optimization, dietary adjustments, and exercise modifications typically produce better results than adding unvalidated combination protocols

Research has shown that AOD-9604 increases the expression of beta-3 adrenergic receptors in adipose tissue, restoring suppressed receptor levels in obese models