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These references make clear that B12 therapy is primarily about treating deficiency, not directly burning fat

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56 In the leaky gut hypothesis, ADH increases the permeability of the intestinal barrier, 57 allowing bacterial endotoxin (LPS) access to the liver via the portal circulation

Given that the primary role of SM-102 in clinical lipid nanoparticles is to facilitate endosomal escape of mRNA, we evaluated the impact of SM-102 incorporation on subcellular localization of 20:0 BPD-PC using confocal microscopy