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In the pituitary gland, it co-localizes with numerous peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotropic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH), and melanin-concentrating hormone (MCH)

The healing effect was similar to two prescription treatments (the proton-pump inhibitor omeprazole and synthetic prostaglandin misoprostol), but was not effective prophylactically (before ulceration had occurred) (Sancar 2009)

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While internal cellular support begins immediately, visible results like improved skin radiance usually take 8 to 12 weeks