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After GSH donates its electron, it becomes oxidized and leads to the formation of glutathione disulfide (GSSG)

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81 However, the potential consequences of chronic MPO inhibition in individuals with COPD who are already at an increased risk of pulmonary inflammation and infection are unknown

[2] The MHRA Drug Safety Update (August 2022) advises healthcare professionals to consider testing vitamin B12 levels in patients taking metformin who develop symptoms of neuropathy or anaemia, and to consider periodic monitoring in those at risk of deficiency