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Thioredoxin-1 protects spinal cord from demyelination induced by methamphetamine through suppressing endoplasmic reticulum stress and inflammation

VAT dropped by about 18% over 52 weeks vs placebo

Since some db/db mice succumbed to this treatment probably due to RIF toxicity at 16 mg/kg, we reduced the dose to 8 mg/kg and treated the animals 3 times weekly through oral gavage from day-4 onwards until 8 weeks post-infection