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The results directly indicated that the targeting motif RGD-binding peptide RGD-GHK almost totally suppressed the collagenase (MMP-1) expression, resisted H 2 O 2 -induced COL-1 degradation, and simultaneously promoted collagen synthesis compared with GHK alone for cell anti-aging performance

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Preclinical studies suggest that GLP-1 signaling in the central nervous system may influence neuronal activity patterns, though the clinical significance of these findings for human fatigue remains theoretical