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1.2 Chronic lung disease NTHi is the leading bacterial cause of infectious exacerbations in adults with chronic obstructive pulmonary disease (COPD) and the second leading cause of infections in paediatric cystic fibrosis (Finney et al., 2014

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Peroxisome proliferator-activated receptor (PPAR) encodes peroxisomal and mitochondrial enzymes that promote fatty acid catabolism, and its protective effects against APAP toxicity were confirmed in several studies [16], [85]