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Model and physiological RS 2 and RSSR substrates are, for example, bis(2-hydroxyethyl)disulfide (HEDS) 1,3,12,14,30 , l-cystine 1,3 , redox-sensitive yellow or green fluorescent protein 2 (rxYFP or roGFP2) 14,15,31,32,33,34,35 , insulin 36,37 , collapsin response mediator protein 2 38,39 , the transcription factor OxyR 40 , 3-phosphoadenosine 5-phosphosulfate reductase (PR) 41,42 , methionine sulfoxide reductase (MSR) 34,43,44 , and ribonucleotide reductase (RNR) 2,34,45,46,47

FIGURE 2 Given the close proximity of the TME to cancer cells targeted by treatment, the TME is invertedly changed during cancer treatment

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