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It serves as a defined tool for studying pancreatic beta-cell function, hypothalamic control of feeding, gastrointestinal motility, and metabolic responses in experimental systems

The necrotic lipid core is covered with a collagen fibre-enriched fibrous cup which is lyzed by activation of matrix metalloproteinases (MMP) in the presence of ROS [189, 190] generating an advanced atheromatous plaque called unstable plaque

Examples of some ROS are: superoxide anion, hydrogen peroxide and peroxyl radicals to name a few

ClinicianPatient Relationship: Commonly lack most signs and symptoms Often present with fatigue Fatigue The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli