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While efficacy matters, the tolerability and adverse effect profile often determines whether a treatment is suitable for long-term use
These include: Older adults on PPIs or H2 receptor antagonists Diabetic patients on metformin for a long time People with gut disorders that affect nutrient absorption Its important to check these individuals B12 levels to avoid deficiency
Gysin R, Riederer IM, Cunod M, Do KQ, Riederer BM
The retracted state places the D2 domain further from the Ub-loaded E2, which is counterintuitive as ubiquitination is driven by proximity
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