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With the addition of icodec, the curve shifts to the right, indicating that there is competitive binding for albumin between semaglutide and icodec leading to more free semaglutide in the presence of icodec at all HSA concentrations owing to the relatively stronger albumin binding properties of icodec

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Abstract Background and Objectives Cagrilintide is a long-acting amylin agonist under development as monotherapy for weight management and as a fixed-dose combination with the glucagon-like peptide-1 receptor agonist semaglutide (CagriSema) for weight management and treatment of type 2 diabetes