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(b) In obese mammals, increased circulating leptin results in reduced LEPR expression across the blood-brain barrier

No human clinical trials have evaluated AOD-9604 for osteoarthritis yet, so discuss the current evidence honestly with your provider before pursuing this specific application

Statistical analysis Statistical analysis was performed using parametric two-way mixed model ANOVA (one factor is repeated-measures) and Student Newman-Keuls test to compare the difference between groups