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Conversely, other studies raise concerns about potential metabolic slowdown and negative impacts on weight loss sustainability, particularly in long-term fasting or in vulnerable populations such as women of reproductive age or individuals with subclinical hypothyroidism [9]

doi: 10.1186/s12958-018-0413-3 22 MoridiIChenATalOTalR

Methotrexate modulates the kinetics of adenosine in humans in vivo

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