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Progesterone and synthetic steroids produce insulin resistance at the post-receptor level in adipocytes of female rats

Moreover, in vitro and in vivo , which in turn, induced FoxO1 and thereby upregulates the gluconeogenic genes G6pc (glucose-6-phosphatases), pck1 (cytosolic phosphoenolpyruvate carboxykinase) in the liver, leading to hyperglycemia

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Its mechanism of action includes glucose-dependent stimulation of insulin secretion, suppression of glucagon release, delayed gastric emptying, and reduction of appetite