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Neuroendocrinology (2000) 71(1):6878
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In the New England Journal of Medicine, Garvey and colleagues [5] report the results of the REDEFINE 1 trial, a 68-week, phase 3a double-blind, placebo-controlled and active-controlled trial evaluating the efficacy and safety of coadministered cagrilintide and semaglutide in adults with obesity [body mass index (BMI) 30 kg/m 2 ] or overweight (BMI 27 kg/m 2 ) with at least one weight-related comorbidity
She cautioned, however, that patients taking weight loss peptides must stay well hydrated and consume enough protein, since the drugs can suppress appetite to the point where adequate nutrition becomes difficult
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