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When GLP-1 receptors on these neurons are activated, the result is reduced hunger, increased satiety, and decreased food preoccupation

They have a similar structure to the hormone glucagon-like peptide 1 (GLP-1), which means taking these medications tricks your body into thinking GLP-1 levels are high

A 6-week phase 1 study of participants without T2D who had overweight or obesity found reduced activation (estimated from blood oxygen level dependent signal functional MRI) in certain brain regions relevant to appetite regulation in response to high-fat/high-sugar food images among participants assigned to tirzepatide 10 mg as compared with placebo [75]

The right GLP-1 depends on your goals, health conditions, budget, and dosing preference