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doi:10.1016/0960-0760(92)90307-5

Common side effects include nausea, vomiting, diarrhoea, and constipation

Enhanced therapeutic window : Hydrogel-assisted approaches mitigate toxicity to bladder, rectum, and bowel while allowing dose escalation

In experiments assessing GST metabolic stability, liver cytoplasm served as the incubation system, with 4-nitrobenzoyl chloride (PNBC) and ethacrynic acid (EA) selected as substrates and inhibitors of GST, respectively [18]