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[Abstract]2023 Jan:310:136924

[21] Other genes from various species have been inserted into the tomato with the hope of increasing their resistance to various environmental factors

IGF-2 is the preferred high-affinity ligand of IGFBP-6, and can activate signaling through both IGF1R and isoform A of INSR

30 Additional Contributors Other conditions that can lead to CKD include 31-33 : Kidney damage caused by the long-term use of certain medications (see section titled What Medications Are Linked to Chronic Kidney Disease? below) Polycystic kidney disease, a genetic condition in which multiple large cysts form in the kidneys Autoimmune disorders such as lupus and Goodpastures disease, in which the kidneys undergo inflammatory damage Recurring or persistent kidney or systemic infections Long-term heavy metal exposure (eg, lead poisoning) Gout and high uric acid (bi-directional relationship) 4 Symptoms of Chronic Kidney Disease A major challenge with CKD is that it rarely causes symptoms before stages 4 and 5