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J., Laughlin-Tommaso, S

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a , C57BL/6 J mice were infected via intravenous (i.v.) tail vein injections and intraperitoneally treated with 10 mg/kg rifampicin (Rif) (q.d.) or 100 mg/kg KL1 (b.i.d.) at 6 h post-infection (hpi) for 2 days

If side effects consistently appear 24-48 hours after injection (near peak concentration) and resolve by day five or six (as levels decline toward trough), you have strong evidence that your symptoms are dose-dependent rather than caused by some external factor