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Tirzepatide: Dual-Receptor Therapy Through GIP and GLP-1 Tirzepatide is different from semaglutide because it activates two hormone-related pathways: GIP and GLP-1

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Through this mechanism, GLP-1RAs may reduce endothelial dysfunction and oxidative stress, both of which are key contributors to sepsis pathophysiology (57)

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USA 117 , 27512760 (2020)

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PAR2 is activated by several soluble trypsin-like proteases and multiple transmembrane-anchored serine proteases (TMPRSSs) (3335), but their roles in PAR2-mediated metabolic control are incompletely understood

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