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It was found that the combined supplementation of 2 M Lup + 0.75 M Vit A in semen cryopreservation extenders significantly upregulated the transcriptional levels of antioxidant genes such as SOD1 , NRF2 and GPX4 , concurrently, a notable upregulated was also observed with Vit A supplementation alone, and these findings further confirm that the addition of Vit A and Lup enhances antioxidant enzyme levels

To understand what these supplements actually dobeyond marketing claimswe need to examine the individual compounds and their evidence bases