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A limitation of our research was the inability to assess the effects of switching from dulaglutide to other GLP-1 receptor agonists, as they were unavailable except in fixed-ratio combinations such as insulin degludec/liraglutide and insulin glargine/ lixisenatide

For example, a review of 15 studies found that overweight individuals who supplemented with CLA for at least six months only lost an average of 1.5 pounds (0.7 kg) more than people in the control group ( Side effects: Taking CLA may result in unpleasant side effects, such as diarrhea and gas

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A more clinically relevant consideration involves metabolic and hormonal interplay : Significant weight loss induced by retatrutide may alter sex hormone-binding globulin (SHBG) levels, which in turn affects the ratio of free to total testosterone