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Methods: In a phase II pharmacokinetics and safety study, five infants (three girls) with a median (range) gestational age (GA) of 26 wk + 6 d (26 wk + 0 d to 27 wk + 2 d) and birth weight of 990 (9001,212) g received continuous intravenous infusion of recombinant human (rh)IGF-I/rhIGFBP-3

Safety Considerations and Side Effect Profiles Metformin is exceptionally safe for most patients, with the primary side effect being gastrointestinal distress in 10-30% of users