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On top of these findings, a dose-response relationship was observed for both semaglutide and orforglipron, suggesting that higher doses may deliver broader cardiometabolic effects

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Compared to the control animals, those administered L-carnitine exhibited increases in L-carnitine metabolites such as L-carnitine (ratio: 4.4), butyrylcarnitine (ratio: 7.7), and O-acetylcarnitine (ratio: 14), and a decrease in the L-carnitine (LC)/acyl-L-carnitine (ALC) ratio (Fig

(PubMed) Muhlhausler BS, Yelland LN, McDermott R, et al