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Overactive NNMT is associated with: Increased fat cell growth Metabolic resistance Depletion of NAD , a critical molecule in energy production and DNA repair Key Pharmacological Actions of 5-Amino-1MQ Summary Table Does It Affect the Brain

Lovejoy JC, Champagne CM, de Jonge L, Xie H, Smith SR

Human studies further support the neuroprotective role of choline

Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism