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Acknowledgements The authors would like to thank Thomas Rohban, MD, and Magalie El Hajj, PharmD, from Partner 4 Health (Paris, France) for providing medical writing support in accordance with Good Publication Practice (GPP3) guidelines

While Tirzepatide activates two receptors (GLP-1 and GIP), Retatrutide adds a third: the Glucagon receptor

Many Medicaid GLP-1 denials are overturned on appeal when additional clinical documentation is submitted

Gut dysbiosis (an imbalance in the microbiome) has also been shown to lead to GLP-1 resistance, meaning your body doesnt properly respond to GLP-1 even when its released