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Concerns about thyroid cancer with GLP1-RA use were first raised in the premarketing phase after studies showed increased rates of thyroid C cell tumours in rodents (1)

for solution products (like Ozempic, Victoza, Trulicity), it should be clear and colourless or slightly yellow

This glucose-dependent mechanism reduces hypoglycemia risk compared to insulin or sulfonylureas

So the commonly cited regain curves reflect a very specific scenario: Sudden withdrawal of potent appetite-regulating therapy Removal of dietary, physical activity, and behavioral scaffolding that supported weight loss during the trial phase That combination almost guarantees weight regain and tells us more about biology plus trial design than about real-world inevitability