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Lotte Bjerre Knudsen (32:02): I don't know about health span, but because certainly there's been so many studies with metformin and there's been a lot of wonderful data showing an effect on the epigenetic clocks, but not really an effect on lifespan because that metformin is so widely used

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In a 48-week phase 2 study of retatrutide involving 338 overweight or obese non-diabetic participants, researchers observed dose-dependent decreases in weight and improvements in waist circumference, blood pressure, levels of glycated hemoglobin, fasting glucose and insulin, and most lipid metrics