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Stronger mechanistic clarification would require isoform-specific NOS inhibition, direct measurement of NO metabolites, eNOS phosphorylation analysis, rescue experiments, and comparison across endothelial, epithelial, fibroblast, and neuronal model systems

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However, NADH remained positively correlated with creatinine and positive correlations also with other muscle metabolism markers creatine kinase and myoglobin appeared (Fig