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Comparison of GLP-/GIP dual agonists and GLP-1 GLP-1 and GIP, both major members of the incretin family, play a physiological role by binding and activating corresponding receptors to promote postprandial insulin secretion [125]

In order to better characterize the role of endogenous GLP-1 in post-prandial hypoglycemia secondary to fundoplication, the insulin response to a standardized mixed meal in affected children was measured with concomitant administration of exendin-(9-39) or vehicle through a continuous intravenous infusion

The medication's anti-inflammatory effects extend beyond weight loss itselfsemaglutide directly activates GLP-1 receptors on immune cells, including macrophages and T cells, modulating their inflammatory response