As of March 2024, there are more than 16 compounds being developed by 11 different companies in late-stage development (phase II or III), an additional 18 compounds in phase I, and approximately 40 in pre-phase I development
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However, HE staining showed slight folding, shrinking and delamination of the basement membrane of seminiferous tubules in the rat testicular tissue, an increasing amount of sperm, insignificant damage to spermatogenesis, a lack of mature spermatogenic cells, a slightly disordered and sparse cell arrangement with 35 layers and visible cell polarity in groups C and D