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3-5% total body-weight reduction was commonly reported
Three realistic paths exist: (1) stay on indefinitely like blood pressure medication, (2) strategic cycling with lifestyle intensification, or (3) transition protocols that may preserve 30-40% of weight loss
Dulaglutide, liraglutide and subcutaneous semaglutide have been approved for reducing the risk of major adverse cardiovascular events in adults with type 2 diabetes mellitus with established cardiovascular disease, dulaglutide is approved for use in type 2 diabetes mellitus with multiple risk factors, and both liraglutide and semaglutide have been approved for chronic weight management
For researchers and institutions: Mandate sex- and hormone-state reporting in trials of diabetes therapies and require pre-specified subgroup analyses
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