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301 Immune dysregulation is a vital pathogenic mechanism of ARDS that is characterized by sustained and excessive activation of the inflammatory response, abnormal elevation of cytokine levels, and suppression of anti-inflammatory responses

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Because DHEA is only converted into sex steroids in target tissues containing the relevant physiologic enzymatic machinery, it has been suggested that it could be used for treating estrogen-deficient wound healing without deleterious systemic side effects (Pomari et al., 2015)