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Its based on studies of the benzyl alcohol's effectiveness over time after a vial has been repeatedly punctured

Thus, it prevents the activation of pain and migraine networks in the brain, including disruption of CGRP activity , which has become a central focus in most of the new migraine medications on the market such as the gepants and CGRP monoclonal antibodies

That is a real risk arguably a greater one than the theoretical risks the FDA cited when it enacted the 2023 restrictions

For most healthy adults, it's clinically insignificant, but people with cardiovascular conditions should discuss topical minoxidil use with a physician