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More than a billion people worldwide are living with obesity, which increases the risk of diseases such as 2 diabetes, cardiovascular disease and cancer

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The article says naltrexone blocks opioid receptors in the hypothalamus, removing inhibition of pro-opiomelanocortin neurons that regulate satiety, while bupropion is a norepinephrine-dopamine reuptake inhibitor that increases alertness and reduces appetite by raising dopamine and norepinephrine in the brain's appetite-control centres

Key Insight : The total GLP-1 spend per member per month has more than tripled from $5.29 in 2020 to $18.27 in 2023 , indicating a rapid and significant shift in healthcare spending patterns