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Biguanide-derived neuroprotective agent (metformin) To mitigate neuroinflammation and mitochondrial dysfunction in PD, metformin was encapsulated into PLGA, which were further coated with BV2 microglial cell membranes to enhance the targeting efficiency to neuroinflammatory sites (BV2-metformin-loaded PLGA) for intranasal administration 19

For weight management, treatment duration may depend on achievement and maintenance of weight loss goals, with some patients requiring long-term therapy to maintain weight reduction while others may successfully transition to lifestyle modifications alone after achieving target weight