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Theranostics 8(3):593609 van der Velde AR, Gullestad L, Ueland T, Aukrust P, Guo Y, Adourian A, Muntendam P, van Veldhuisen DJ, de Boer RA (2013) Prognostic value of changes in galectin-3 levels over time in patients with heart failure: data from CORONA and COACH
to improve the indices of cardiovascular, endocrine, immune and nervous systems, homeostasis and metabolism. The researchers observed a 1.6-1.8 fold decreased mortality rate in the epithalamin-treated group, as well as decreased rates of: Coronary artery disease Hypertension Osteoarthritis Osteoporosis The researchers concluded that epithalamin may be beneficial for health maintenance and age-related pathology prevention in elderly subjects
Adverse effects observed in clinical trials include: Gastrointestinal effects: nausea, vomiting, diarrhoea, and constipation particularly during dose escalation
However, the current findings remain inconsistent, which may be attributed to factors, such as limited sample sizes, population heterogeneity, and confounding variables including dietary differences, medication use, geographic region, and lifestyle
