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GHK-Cu regulates extracellular matrix remodeling, BPC-157 aligns collagen fibers, TB-500 promotes orderly cellular migration, and KPV reduces free radical-mediated tissue stiffening, resulting in smoother, functionally superior regeneration outcomes

Acknowledgements We thank the trial participants and the investigators and trial coordinators who cared for them as well as the members of the data monitoring committee

We highlighted the summary of the advantages and disadvantages of each route in (Fig