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I remember training before my last US Open

The group receiving the highest retatrutide dose of 12mg/weekly experienced a significant 24.2% reduction in weight, compared to a modest 2.1% reduction in the placebo group [21]

95% CI, 0.901.63) (81)

Though several molecules, such as mazdutide, a GLP/glucagon dual agonist, are being studied in various phases, the first agent targeting incretins other than just GLP-1 was approved in 2022 tirzepatide [41]