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Semaglutide is similarly effective in those with and without HF and in both HF with preserved ejection fraction (HFpEF) and with reduced ejection fraction (HFrEF)

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There were significantly fewer events in the empagliflozin group for death from CV causes, death from any cause, and hospitalization for heart failure (this is important because some other antihyperglycemic agents have been associated with more heart failure)