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Systemic or central administration of GLP-1 activates satiety centersparticularly the arcuate and paraventricular nuclei, the nucleus tractus solitarius, and the area postrema, thereby suppressing hunger [52]

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Environmental pollutants can enter the human body through respiratory inhalation (PM2.5, benzo[a]pyrene, etc.) [2], food chain ingestion (2,3,7,8-tetrachlorodibenzo-p-dioxin) [3], and dermal contact (phthalate esters) [4], etc