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2, confirming our modelling

Ivabradine effectively decreases heart rate while preserving myocardial contractility and coronary vasomotor responsiveness, reducing oxygen consumption and extending diastolic duration (16)(17)

3) is the maintenance of tissue homoeostasis at all the levels of CNS organisation, from molecular (ions, metabolites, and neurotransmitters, etc.), to network (regulation of synaptic connectivity), to organ (formation and maintenance of bloodbrain barrier and glymphatic clearance system) and systemic (chemosensing blood oxygen, Na + , CO 2 or glucose)

For use in vitamin B12 deficiency associated with cobalt deficiency in cattle and sheep and for vitamin B12 deficiency associated with inadequate vitamin B12 intake or intestinal malbsorption in swine and horses