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How sublingual tirzepatide works differently from injections Before touching a single number on the dosage chart, you need to understand why sublingual dosing exists as its own category

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While some studies found no difference between individuals with T2DM and matched non-diabetic controls (6769), others found plasma DPP-4 activity to be reduced in the patients, and suggested this might reflect a compensatory response to the reduced insulin sensitivity and hyperglycaemia, in an attempt to increase intact incretin hormone concentrations and improve insulin secretion (70, 71)

Tamori Y, Sakaue H, Kasuga M