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343 Evexomostat (SDX-7320), which irreversibly binds METAP2 and regulates insulin, leptin, and adiponectin downstream, was one of the first drugs developed for cancer patients with metabolic complications

Animal models demonstrate its capacity to promote nerve regeneration and protect against brain damage from trauma or toxins

This progress in scientific development enables a 1-week administration of the drug, making them an efficient alternative to other antidiabetic drugs, such as metformin, which requires two daily doses, and the updated metformin, which requires daily doses [100, 101]

J Pharmacol Sci 108:717 Klicek R, Kolenc D, Suran J et al (2013) Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and colon-colon-anastomosis and counteracts cuprizone brain injuries and motor disability