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But before starting a GLP-1 program, its important to understand that medication is only one piece of the puzzle

Moreover, they found that folic acid could repress ferroptosis in nucleus pulposus cells by downregulating the methylation level of GPX4 [151]

In the sections that follow, we build on this conceptual framework to examine how major proteostasis machineries contribute to cellular and organ-level resilience and how their failure drives pathology across cardiovascular, cancer, metabolic, neurodegenerative and autoimmune disorders and highlight therapeutic strategies aimed at reinforcing proteostasis resilience