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Once reconstituted , adding more water to change the concentration is technically possible but not recommended
The analysis included eight randomized controlled trials with 2,372 participants (all with BMI 27 kg/m) and found that weight regain was proportional to the amount initially lost.48 On average, participants who had taken liraglutide regained 2.2 kg, while those who had taken semaglutide or tirzepatide regained 9.69 kg after stopping the medication.48 Similarly, a 2025 review in Biomolecules showed that patients treated with GLP-1 or dual GLP-1/GIP agonists experience substantial weight loss (ranging from about 6% to over 20%) but also significant weight regain upon drug discontinuation
Experts on Konzo who are based at the University of Kinshasa and Institute National de Research Biomedical (INRB) helped design and execute the research activities presented in this manuscript, in collaboration with the large group of co-authors who aided in research activities related to this work
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