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GO analysis revealed that sermorelin-associated genes were predominantly involved in processes linked to cell proliferation, such as nuclear division and cell cycle regulation

confirmed that intranasal Semax application induces rapid, gene-specific and region-specific neurotrophin mRNA changes across the rat brain including BDNF upregulation in the hippocampus, brainstem, and cerebellum establishing a comprehensive transcriptional neurotrophin signature that goes beyond a single brain region or gene target

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