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Oral semaglutide linked to significant weight loss as Novo Nordisk awaits FDA approval Oral semaglutide can help overweight and obese patients lose significant weight, according to new data published in The New England Journal of Medicine .[1] Semaglutide is a GLP-1 receptor agonist sold by Novo Nordisk under the brand names Wegovy and Ozempic

Research indicates that Semaglutide exerts its effects through both peripheral and central mechanisms: Central Nervous System (CNS) Signaling: Semaglutide crosses the blood-brain barrier, interacting with GLP-1 receptors in the hypothalamus (specifically the arcuate nucleus) and the hindbrain

The SURMOUNT-1 trial (tirzepatide, published in NEJM 2022) demonstrated that participants with obesity or overweight without diabetes who received tirzepatide experienced weight reductions of 16.0% (5mg), 21.4% (10mg), and 22.5% (15mg) over 72 weeks

[2] [5] Other important safety considerations include risk of diabetic retinopathy complications, gallbladder disease, and acute kidney injury