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Supplementation may be useful in selected circumstances, but it remains one part of a much larger biological system

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The position this article takes, given those three valid critiques, is that the mechanism evidence is strong enough, the delivery evidence is biologically plausible enough, and the safety window is wide enough that the recommendation is defensible

The compounded methylene blue anti-aging cream uses 0.0064 percent methylene blue, well below the approximately 0.05 percent threshold at which visible blue staining occurs on skin