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Cyclins D1 and D3 are dysregulated in childhood acute lymphoblastic leukemia

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Main body Anthracyclines, particularly doxorubicin, have emerged as crucial components in cancer treatment, demonstrating significant antitumor activity across various malignancies

This effect is due to an improvement in hepatic clearance and peripheral disposal of glucose in response to a correction of chronic hyperinsulinemia.88,89 However, liver transplantation cures DM only in 67% of cases